Muscular dystrophy Cause 
Related Questions: Muscular dystrophy, Muscular dystrophy cause
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These conditions are inherited, & the different muscular dystrophies follow various inheritance patterns. The main cause of Duchenne & Becker types of muscular dystrophy is the inpower to properly create the protein dystrophin. Dystrophin protein is found in muscle fibre membrane, it acts like a massive spring. It joins the membrane actin filiments. The protein is rod shaped around 150nm in length, 3684 amino acids long, 427kDa molecule weight. It is hydrophobic . Conformation is alpha-helical, allowing protein to act as a shock absorber, preventing overstress. Dystrophin links actin & dystroglycans of the muscle cell plasma membrane, known as the sarcolemma . Dystrophin roles in 2 ways mechanical stabilisation & regulated calcium levels. Muscular dystrophy Answer above is based on work by authors at wikipedia.org. Text above is available under Creative Commons Attribution-ShareAlike 3.0. posted by Kerry on 25 May 2011 13:27
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